Rapid drop in serum potassium concentration may occur after treatment with this medication monitor frequently, especially after first several hours of administration Renal failure
Suicidal ingestion may result from more than one drug toxic effects of other drugs or poisons should not be overlooked, especially in cases where signs and symptoms of digitalis toxicity are not relieved by administration of this medication
Serum digoxin levels rise after digibind treatment - do not use serum levels to guide continuing treatment >5 mEq/L in setting of severe digoxin intoxication, especially if increased creatinine May be given IVP for life-threatening dysrhythmias Other Indications & Usesįor life-threatening dysrhythmias or hypotension unresponsive to other measures caused by digoxin, digitoxin or related toxins (ie, foxglove) Total digoxin load (mg) divided by 0.5 mg digoxin bound per vial = number of vials to use Toxicity During Chronic TherapyĪcute distress or for whom a serum digoxin concentration is not available: Administer 6 vials Renal Impairmentĭose adjustment not necessary but use caution as digoxin immune Fab complex is renally eliminated AdministrationĪdminister by IV infusion over 15-30 minutes (see IV information) Larger dose has faster onset, but may cause febrile reaction may give 10 vials initially, then at physician's discretion, administer 10 more vialsĮach vial of DigiFab (40 mg of Fab) binds 0.5 mg digoxinĮquimolar dose to ingested digoxin (76/80 mg FAB = 1 mg digoxin) Acute Ingestion of Known Amount
Dosage Forms & Strengths powder for injection
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